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This theory is that free radicals, as by-products of mitochondrial oxidative metabolism, cause cumulative cellular damage that results in overall loss of organismal fitness over time

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Br J Surg 2002;89:16371

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"Signaling through G-Protein-Linked Cell-Surface Receptors", Molecular Biology of the Cell

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The identification of additional members involved in the AITC-induced responses is a key step to fully understand the complexity of this physiological process

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We have recently found that inhibiting the ADM/NO signaling pathway can indeed reduce the neuronal pathology in early DR

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