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In conditions such as MS, Th17-driven inflammation contributes to neurodegeneration and tissue damage [138]
GHRH is derived from a 108 amino acid prepro-hormone to give GHRH (1-40) and (1-44) (Figure 6), which are both found in the human hypothalamus (310,311)
Significant myelin and axonal damage have also been detected in HD (Di Paola et al., 2012) and may underlie the WM changes observed in this condition
