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In contrast, in diseases characterised by mitochondrial dysfunction and bioenergetic failure (often reflected by reduced FDG-PET signal), elevated iron may instead represent a compensatory response to functional iron deficiency rather than a pathogenic surplus

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doi: 10.1016/j.plefa.2017.05.004
Leaving these off can cause rejections

pmc.ncbi.nlm.nih.gov Equine administration &
