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[DOI] [PMC free article] [PubMed] [Google Scholar] 57.Chen L et al

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This short-term intravenous regimen is useful for acute correction of severe hypomagnesemia, but is not suitable for long-term management of chronic liver diseases due to practical constraints and the risk of hypermagnesemia, particularly in patients with coexisting renal impairment

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Mechanistically, methotrexate inhibits several enzymes that participate in nucleotide synthesis, including DHFR, TYMS, aminoimidazole caboxamide ribonucleotide transformylase (AICART), and amido phosphoribosylltransferase