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APAP is bioactivated to N -acetyl p -benzoquinone imine (NAPQI), a reactive metabolite, which can subsequently covalently bind to glutathione and protein thiols
Misuse and abuse of hydrocodone bitartrate and acetaminophen tablets increases risk of overdose, which may lead to central nervous system and respiratory depression, hypotension, seizures, and death
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The determination of specific metabolic pathways and/or molecular targets disrupted after the simultaneous exposure to different neurotoxicants is also required, particularly on how the binary, tertiary, quartenary, etc
10.3748/wjg.v20.i26.8660 166
