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NAC is not necessarily better than glutathione for detoxification, but it works differently
Fundamental biological features of spaceflight: advancing the field to enable deep-space exploration
However, sustained cytosolic Ca 2+ elevations can exceed mitochondrial buffering capacity, leading to matrix Ca 2+ overload, enhanced electron leak at complexes I and III, and increased mitochondrial ROS (mtROS) generation (Lonobile et al., 2025)
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114116 Both can also generate oxidant stress and LPO, which can be inhibited by lipophilic antioxidants such as vitamin E
