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Mendelian randomization was used to analyze data from 265 gene variants known to be associated with IGF-1 concentrations in 122,977 women with breast cancer and 105,974 women without cancer

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Retrieved from Pawlak, R., Lester, S

Clinical Pharmacology and Therapeutics

In addition, a specific miRNA may exert multiple regulatory effects by binding to several targets of metabolic signaling pathways, illustrated by the example of let-7 that binds to 3UTR regions of INSR, IRS-2, and IGF-1R and regulates their expression (95)