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However, some BET inhibitors as single-agent therapies have shown mixed outcomes in clinical trials for distinct cancer settings, despite their excellent results in preclinical models

In addition, with the recognition of various modes of cell death, the original necrosis or oncotic necrosis [79] was challenged to be apoptosis [14, 15], necroptosis [16, 17], and lately ferroptosis [18, 19] and even pyroptosis [20, 21]

380 TNF The TNF signaling pathway has proved amenable for therapy of autoimmune and other chronic inflammatory noninfectious diseases

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