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J Hepatol 73:S124

GLP-1 mediates its effects through binding at a transmembrane receptor (GLP-1R), found on pancreatic cells and CNS neurons

After a decade of human genetics studies focusing on disease risk, emerging results from genetic studies of disease progression suggest a multi-hit paradigm in which disease initiation and disease progression are not necessarily driven by the same mechanisms (Figure 3)

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BMJ (Online) 349
