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Another study found that after six days of treatment of valproic acid with a dosage of 300 mg/kg, there was a reduction in angiotensin II and a reduction in HDAC1 expression in a high-fat-diet rat model (Choi et al., 2017)
The Journal of Physiology
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Specifically, in CRC cells, TMAO has been proved to promote proliferation and potential angiogenesis by upregulating vascular endothelial growth factor A (Yang S
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