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MT-1 appeared to modulate matrix metalloproteinase (MMP) activity, increasing the expression and enzymatic activity of collagen-degrading enzymes, including MMP-1, MMP-2, and MMP-8

Because of the intestinal CYP3A4 and p-glycoprotein inhibition, a careful monitoring for drug interactions is a mandatory precaution

A consistent 250mcg daily protocol will outperform sporadic 500mcg doses