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11 Chronic Obstructive Pulmonary Disease and Reactive Oxygen Species Lungs are particularly vulnerable to oxidative stress due to the high oxygen environment and exposure to environmental pathogens and oxidants

doi: 133

D.KronembergerA.BaeD.BockJ

Atwood CS, Huang X, Moir RD, Tanzi RE, Bush AI (2018) Role of free radicals and metal ions in the pathogenesis of Alzheimers disease

While enzymes such as glutathione peroxidase 4 (GPx4) typically utilize cellular glutathione (GSH) stores to scavenge lipid hydroperoxides and prevent LPO-induced damage, erastin-mediated inhibition of cysteine uptake through the Xc- transporter compromises this defense strategy, leading to cell death
