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Adiponectin or activation of adiponectin receptor 1 (AdipoR1) can upregulate multiple hair growth factors through AMP-activated protein kinase (AMPK) in human follicular DPC, including IGF-1, vascular endothelial growth factor (VEGF), IGF, HGF, PDGFA, and FGF 7, and downregulate TGF1, thereby inducing the anagen and promoting hair growth ex vivo and in vivo 100 - 103

Furthermore, studies have highlighted that ROS can activate the sympathetic nervous system (120), suggesting that the sympathetic nervous system may be less inhibited under high oxidative stress

Similarly, for patients managing chronic diseases such as diabetes, cardiovascular conditions, or neurodegenerative disorders, combining neuro-nutrition and exercise can improve insulin sensitivity through dietary polyphenols and aerobic exercise, reduce systemic inflammation with anti-inflammatory diets like the Mediterranean diet coupled with physical activity, and slow cognitive decline by increasing hippocampal neurogenesis