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Metformin has been associated with reduced vitamin B12 absorption through effects on calcium-dependent membrane action in the terminal ileum, which may be relevant for patients on chronic metformin therapy

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The blog notes its research-focused use and the need for additional studies to prove long-term benefits while highlighting its safety and efficacy and highlighting its potential for weight management and general metabolic health

All of that being said, if your dog has previously had a reaction to a vaccine always inform your vet ahead of time

Education into practice Practice How often do you evaluate B 12 deficiency related symptoms in individuals at high risk of developing this, such as vegetarians and vegans, or people with increased risk of B 12 malabsorption, such as individuals with type 1 diabetes or Hashimoto hypothyroidism