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Mitochondrial bax translocation accelerates DNA fragmentation and cell necrosis in a murine model of acetaminophen hepatotoxicity

Eluted protein was further purified by HiTrap Heparin HP affinity column (Cytiva, 17040703) with a linear gradient of Low-Salt Wash Buffer (50 mM HEPES-NaOH pH 7.4, 50 mM NaCl, 2 mM EDTA, 10% Glycerol, and 2 mM DTT) and High-Salt Wash Buffer (50 mM HEPES-NaOH pH 7.4, 1 M NaCl, 2 mM EDTA, 10% Glycerol, and 2 mM DTT) to remove RNA contamination

Moreover, Cadherin-11, an adhesion molecule expressed in fibroblasts, can activate MMP which in turn lead to more collagen deterioration and enhanced elastic fibers in the skin

Ischemia-reperfusion (I/R) injury is linked to endoplasmic reticulum stress (ERS) and mitochondrial dysfunction, resulting in oxidative stress-induced acute kidney injury

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