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While NADPH is essential to regenerate most key antioxidant molecules, it also plays an important role in generating ROS through the action of NADPH oxidases (NOX)

Pyroptosis, another mode of cell death, is triggered by inflammatory vesicles and is characterized by the discharge of substantial quantities of proinflammatory cytokines, such as IL-18 and IL-1

The laser emitted a continuous array of 60 fs pulses at a repetition rate of 80 MHz, average power of about 50 mW

The source of increased iron in microglia and macrophages is multifactorial and includes the death and damage to iron-rich oligodendrocytes, vascular damage, and infiltration of peripheral immune cells involved in systemic iron homeostasis [180]