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The data on rhIGF-1 support the mechanistic rationale that an IGF-1 analog like LR3 (which has extended half-life and greater receptor availability in research settings) could enhance protein synthesis, stimulate cellular proliferation pathways and promote more efficient nutrient partitioning, though direct clinical trials of IGF-1 LR3 itself in humans are lacking

Asked if he thought the substance was legal when he was taking it, Watson replied: "that it was legal at the time and that was actually what I was told I was being given." Essendon are under Australian Sports Anti-Doping Authority (Asada) and AFL investigations for last year's supplement program

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