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Cancer Res 70(15):61716180 Yang J, Yan J, Liu B (2018) Targeting VEGF/VEGFR to modulate antitumor immunity

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Consequently, activation of these cascades leads to a reduction of the pro-inflammatory cytokine release, including tumor necrosis factor alpha (TNF-), interleukin 6 (IL-6), IL-1, Il-17, IL-2, and interferon (INF-), the so called non-T helper cells 2 (Th2)-mediated cytokine profile (Figure 2), and reduction in adhesion molecule release including vascular cell adhesion protein 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), and E-selectin

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