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Acknowledgments The authors would like to acknowledge the administrative and technical support provided by the staff of IRCCS San Raffaele Hospital and University Vita Salute San Raffaele

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THE IMPORTANCE OF TIMING: A CENTRAL HYPOTHESIS The seemingly contradictory effects of melatonin on glucose metabolism may appear difficult to reconcile at first glance, but they are consistent with the Timing Model proposed here

Products Are Not Approved for Human or Animal Use Products are not offered as drugs, compounded preparations, medicines, dietary supplements, foods, cosmetics, medical devices, or veterinary products

Our laboratory has a long history of studying the effects of stress on brain circuits implicated in depression, says McEwen
