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Notably, GSH metabolic genes and GSH production in astrocytes can be up-regulated in neuronal co-culture through the modulation of astrocytic Nrf2 [77]

PMC 478481

That is, it may take actions primarily by inhibiting FTO to correct upstream metabolic dysregulation, and concomitantly by dampening the downstream inflammatory cascade and oxidative stress that directly fuel nociceptive and neuropathic signaling pathways

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