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Reactive astrogliosis is an evolutionarily conserved, graded, context-specific and multistage defensive response of astrocytes to neuropathology governed by complex molecular programs that translate into biochemical, morphological, metabolic and physiological features of astroglia, leading to an upregulation or loss of homeostatic cascades, or to the gain of new protective or regenerative functions 9,118

doi: 10.1002/jsfa.11181 283 PalaciosANavarro-RiveroMEZouBJiangZHarrisonMTDingY

For women with PCOS who have exhausted conventional ovulation induction, kisspeptin represents a meaningful clinical frontier one to watch closely, not one to pursue outside of a structured trial

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p53 is upregulated during MSC senescence and osteogenesis, correlating with increased expression of miR-145a, which is induced by p53