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Uremic toxins induce kidney fibrosis by activating intrarenal renin-angiotensin-aldosterone system associated epithelial-to-mesenchymal transition

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Moreover, NRF2 induces the gene expression of SESN2 and PINK1 to promote macroautophagy and mitophagy in the cell response to oxidative stress, respectively [121, 122]

This complex activates caspase-9, which subsequently triggers the activation of downstream caspases-3 and 7, consequently initiating a cascade of caspase reactions that leads to apoptosis (Fig

17(12):CR677-82