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114 Additionally, ER can engage directly with other proteins, including those involved in growth signaling pathways, which, in turn, amplifies the transcription of genes that are pivotal for cellular expansion and resistance to apoptosis

Examples of circadian-regulated physiological pathways includes cell growth, DNA repair and damage, angiogenesis, apoptosis, metabolism, redox state, as well as immune and inflammatory processes 25,26,27,28

Pediatrics 1998;101:E9 (abstract)

More targeted research has examined tirzepatide's effects specifically on NAFLD and NASH
