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Acknowledgements This work is supported by the Junior Group Leader program of the Rudolf Virchow Center, University of Wrzburg and Deutsche Forschungsgemeinschaft (DFG) FR 3746/3-1 to J.P.F.A., the DFG CO 291/5-2 and CO 291/7-1, the German Federal Ministry of Education and Research (BMBF) through the Joint Project Modelling ALS Disease In vitro (MAIV, 01EK1611B) and the VIP+ program NEUROPROTEKT (03VP04260), as well as the m 4 Award provided by the Bavarian Ministry of Economic Affairs, Regional Development and Energy (StMWi) to M.C., the Cancer Research UK (CRUK, grants C29637/A20183 and C29637/A21451) to E.W.T., the European Research Council (LipidArrays) to V.O., the Natural Sciences and Engineering Council of Canada and the Canada Foundation for Innovation to D.A.P