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It should not be co-administered with drugs that are known to be strong CYP2C19 inhibitors, such as voriconazole and fluvoxamine

Folate deficiency leads to the accumulation of homocysteine which is associated with an increased risk of cerebrovascular diseases, depression, and dementia, with a focus on vascular dementia and Alzheimers disease (, , )

Moreover, its shortcomings have been linked to disturbed homocysteine metabolism, which is associated with various conditions including cancer and cardiovascular disease [52, 53]

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