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Description
Activation of the NF-B pathway leads to the increased production of ROS, creating a positive feedback loop that amplifies oxidative stress and promotes cell apoptosis, contributing to tissue damage and organ failure [228]
Consensus Nomenclature for the Mammalian Methionine Adenosyltransferase Genes and Gene Products
Br J Pharmacol 176(2):189196
Those changes reversed after discontinuation, with skin tone returning to baseline within 6 months
Lysosomal acidification and enzymatic activity depend on V-ATPase proton pumps and membrane proteins (e.g., lysosomal associated membrane protein 1 (LAMP1), LAMP2) [155]
