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Experimental models of bone defects have shown that, when SVVYGLR was implanted together with a collagen sponge, an upregulation of osteogenesis and angiogenesis was observed [169, 239]
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In human astrocytes, S1PR1 activation by siponimod improved Ca 2+ signaling and receptor internalization (162), while it inhibited NFB by nuclear translocation of Nrf2, a regulator of antioxidant response (64)
