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These variants affect the catalytic activity or decrease the transcription of the Cyb5R enzyme in RBCs (soluble form) and other cells (membrane-bound form)

doi: 10.1152/japplphysiol.00630.2003 39
Physical activity may alter the secretion of signaling proteins from skeletal muscles [20]
Obesity is associated with metabolic dysregulation and persistent inflammation [122]
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