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With disease progression, the immune response undergoes a gradual transition toward Th2 polarization, accompanied by elevated expression of fibrogenic cytokines, including IL-4 and IL-13

The most prevalent NDs include Alzheimers disease (AD), Parkinsons disease (PD), amyotrophic lateral sclerosis (ALS) and Huntingtons disease (HD)

Vaidyanathan et al., 2003)

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Oxidative stress caused by a variety of agents and drug-resistant tumor cell lines are two conditions associated with increased cell GSH levels, GCL activity, GCLC mRNA levels and GCLC gene transcription (Mulcahy et al., 1994a