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Cell 76 , 220231 (2019)
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[DOI] [PMC free article] [PubMed] [Google Scholar] 48.Townsend DM, Tew KD
The liver is responsible for the biotransformation of chemicals into less harmful forms, making them water-soluble, which makes it possible for the kidneys to excrete them afterward
This decrease in transport efficacy manifests as diminished synthesis of ceruloplasmin within the serum and a compromised ability to excrete copper through the biliary ducts
