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As the purpose of the intra-luminal guidance is to direct the axon growth cone across the gap, once the first axons have bridged the gap, the presence of intraluminal guidance is no longer necessary and its degradation provides more space to fill by the native ECM [51]
Jorgensen JO, Flyvbjerg A, Lauritzen T, Alberti KG, Orskov H, Christiansen JS
In the adult brain, BDNF also supports neurogenesis in the hippocampal dentate gyrus, one of the few brain regions where new neurons continue to form throughout life
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