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CoQ10 is most highly concentrated in tissues with the greatest energy demands the heart, liver, and kidneys

[2] Lombard et al

Discontinue use (2) two weeks prior to surgery

This is important in tissues that rely heavily on fat as a fuel source, like skeletal muscle and the heart

This mechanism represents a control of the influx of fatty acyl units into mitochondria in response to the intra-mitochondrial acetyl-CoA level, in addition to the finely regulated mechanism of CPT1 by malonyl-CoA
