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For cells such as neurons, the mitochondria must fine-tune the exchange of various cations, including Na + , Li + , K + , and H + , to maintain the outflow of Ca 2+ from the mitochondrial matrix [55]

You also face practical challenges: more injections, more reconstitution, more timing coordination, more variables making it difficult to identify what is actually working

Sun et al., Vascular endothelial growth factor-loaded poly-lactic-co-glycolic acid nanoparticles with controlled release protect the dopaminergic neurons in Parkinsons rats

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Similarly to findings in the VTA, decreases in phosphorylated ERK in the NAc have been associated with the incubation of heroin seeking that is induced by drug cues during periods of abstinence 88