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This is probably due to the less efficient production of H 2 S n from H 2 S compared to that from 3MP

[DOI] [PMC free article] [PubMed] [Google Scholar] 59.Seitz H K, Simanowski U A, Garzon F T et al

4.2 Cytoglobin (CYGB) ROS amplify TGF-/NOX signaling in HSCs (Section 3.2) and sustain tumor-promoting circuits (Section 3.3)

The only clinical study that was designed to define a harmful threshold involved patients with cardiac arrest in which a PaO 2 threshold of 300 mmHg was identified, but this study was retrospective and other confounders could not be excluded 91

However, the Drugs and Lactation Database (LactMed), a definitive resource on such matters, states that milk thistle is "unlikely to adversely affect the breastfed infant" and that it's "generally well tolerated in adults with only mild side effects.21 Of course, no supplement is without its risks, so if you're considering milk thistle as a lactation aid, we recommend speaking with your doctor to confirm its suitability for you and your baby