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Research reveals that some chemotherapy-induced senescent cells may initially contribute to administration efficacy through SASP-mediated immune activation, but their persistence can promote tumor recurrence and administration resistance

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We understand the caution expressed by the reviewer to be based on the review by Serras-Millas quoting work by Tamura and colleagues (Thrombosis Research 128, 55-61, 2011)

The vaccine has been used in infants for more than 40 years and is considered both safe and highly effective at preventing chronic hepatitis B infection in young children, a condition that carries a high risk of liver disease and premature death

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