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268 Other agents proven effective in cardiomyopathy (eg, b -adrenergic antagonists) should also be considered

Inhibiting HK2 curtails the first committed step of glycolysis, reducing glucose-6-phosphate accumulation and its diversion into the PPP, while LDHA blockade prevents pyruvate-to-lactate conversion, averting extracellular acidosis and mitochondrial fragmentation

The Rho Kinases: Critical Mediators of Multiple Profibrotic Processes and Rational Targets for New Therapies for Pulmonary Fibrosis

Body weight of WT treated with eFT508 or vehicle after 24 h fasting (n = 4 mice)