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56 When neuronal membranes are damaged, intracellular Ca 2+ homeostasis is perturbed, which can cause ER stress and potentially apoptosis

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Intracellularly, pemetrexed is polyglutamated by a reaction catalysed by folylpolyglutamate synthase

This may be because their inhibitory activity is disrupted in vivo or they are unable to counteract chronic mucosal inflammation in UC

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