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Summary Report, 2011

Alterations in the normal function of excitatory amino acid carrier 1 affect cysteine transport and GSH synthesis impairing zinc homeostasis (the thiol group of GSH can function as a principal Zn 2+ chelator for the maintenance of Zn 2+ homeostasis in neurons) and oxidative stress, enhancing susceptibility to ischemia-induced neuronal cell death in the hippocampus (162164)

This situation contrasts sharply with approved peptide drugs, which must meet rigorous quality standards

Collectively, these findings indicate that HDAC9 is dynamically regulated during aging and in the context of AD pathology

Cholinergic modulation of the immune system presents new approaches for treating inflammation