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Identification of Key Amino Acids Responsible for the Substantially Higher Affinities of Human Type 1 3-Hydroxysteroid Dehydrogenase/isomerase (3-HSD1) for Substrates, Coenzymes, and Inhibitors Relative to Human 3-HSD2

The pathogenesis process mostly accepted in CF indicates a relative dehydration and a reduction in airway surface liquid volume.8 Therefore airway hydration is an important goal in the overall therapeutic management of this disease

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MAT2B gene codifies for a catalytic subunit that associates with MATII enzyme, is expressed in extrahepatic tissues and during liver development [122,123]

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