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An additional difficulty in diagnosing cobalamin deficiency occurs in patients taking oral vitamin B12 supplementation who do not have absorption disorders

J Biol Chem (2011) 286(39):3416474

This is not like mixing a protein shake where close enough works fine

In this context, we also demonstrated that the disruption of the cellular redox buffer, controlled by GSH, increases not only the oxidative stress (Filomeni et al., 2005a), but also the endogenous physiological flux of NO in neuronal cells ( S -nitrosylation, and DNA strand breaks in neuronal cells

These enzymes are able to act as a conduit for electrons from nascent polypeptides to the ER oxidases