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Furthermore, heritability estimates range from 30 to 40% (Girgenti et al., 2021) with genome-wide studies implicating immune-linked loci such as ANKRD55 among others (Stein et al., 2016

Metabolic concerns (central weight gain, low muscle mass) that may improve when testosterone and gonadotropins normalize, as suggested in emerging data

Central and medial amygdaloid brain-derived neurotrophic factor signaling plays a critical role in alcohol-drinking and anxiety-like behaviors

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We are very grateful to Donatella Pascai, Giuseppina Dibenedetto and Martina Ippoliti for their expert organization and performance of blood sampling