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The most common signs and symptoms of chronic primary adrenal insufficiency are listed below: Lethargy & weakness Nausea & vomiting Abdominal pain Anorexia & weight loss Hypotension Hyperpigmentation - occurs on the exposed areas of the body, points of friction or in palmar creases (Fig

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When your brain perceives a threat, the hypothalamus releases CRH, which signals the pituitary to release ACTH, which tells the adrenal glands to produce cortisol

Concurrently, hyperglycemia-induced oxidative stress impairs Treg function, reducing the production of TGF- and IL-10, thereby weakening anti-inflammatory regulation (64)