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Illuminating the Onco-GPCRome: novel G protein-coupled receptor-driven oncocrine networks and targets for cancer immunotherapy
doi: 10.3389/fncel.2017.00014 13 IsenoviEMuniyappaRMilivojeviNRaoYSowersJR

Loss of the normal hepatocytic architecture, vacuoles, degeneration of hepatocytes with pyknotic nuclei (black square& black arrow), fibrosis and congestion around the portal area (black circle), dilation and congestion of portal vein (blue dotted arrow), congestion in hepatocytes and blood sinusoids (black dotted arrow), bi-nucleated hepatocyte (green dotted arrow) were seen in the photomicrograph of T.S in the liver of Tadalafil-treated rabbits [Fig 2C]

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NADPH oxidase activity was found to increase in the mice without ACE2
