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PMID: 42082057 Fundam Res2025 Dec 16
Classical and alternative NF-kB activation pathways and their roles in lymphoid malignancies

Possible side effects may include mild gastrointestinal discomfort, headache, or temporary flushing, depending on the method of delivery

Therefore, absorption through Peyers patches in the ileum that consists of lymph nodes can be explored as a potential alternative for protein and peptide drugs (Mahato et al., 2003
A topical agent producing systemic immune modulation is unusual and suggests these peptides may be absorbed sufficiently to affect immune function beyond the site of application
