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Description
Further, mitochondrial structural damage compromises membrane integrity, which allows the release of mitochondrial contents such as mtDNA, cardiolipin, and mitochondrial proteins into the cytosol

10.1016/j.chest.2016.08.1440 Chest

The second side effect is extremely uncommon because caffeine relaxes the smooth muscle in the large intestine

Not catastrophic, but worth noting

10.1016/j.psj.2023.103201