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Some researchers eventually use up to 100mg daily for enhanced effects, though this should be approached gradually

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2013, and FDA's December 2024 review lists the same trial set

Every plan is reviewed by a licensed healthcare provider before medication is dispensed

After being fed HFD for a total of 16-weeks (an appropriate rodent model of DIO and comparable to human obesity [21]) and reaching pre-arrival body weights (~38g), mice were randomized into balanced control and treatment cohorts (n=9/cohort), with similar group average body weight and standard deviation