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Inhibitors of selected HDACs possess neuroprotective and neuroregenerative properties in animal models of brain diseases and have been suggested as promising therapeutic drugs [65]

Conclusion In summary: with concurrent measurement of GABA+, Glx and BOLD in response to a cognitive task, we obtained behavioural, functional MR and spectroscopy findings consistent with literature based on separate acquisition of fMRI and MRS, and indicative of an executive and attentional deficit

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It is not FDA-approved for human therapeutic use, and most evidence involves preclinical studies, animal models, and limited early human safety data

In simple terms, the denaturation of a protein means that its three-dimensional structure has begun to unfold