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If your body perceives a supplement as a threat, it may release histamines

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Shao, C., Wang, J., Tian, J

For example, oxidation processes and/or reactive LIP in the medium or the serum in vivo may produce H 2 O 2 in the extracellular space in both normal and cancer cells, in which case pharmacological Vit-C would have no therapeutic advantage over alternative pro-oxidant treatments