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IGF-IR promotes epithelial-mesenchymal transition (EMT) and stemness It is conceived that dynamic EMT and mesenchymal-epithelial transition drive cancer cell invasion, survival in circulation, and outgrowth in secondary organs

Experimental findings indicate that IGF-1 LR3 may counteract some of myostatins inhibitory actions on muscle cell proliferation

4.1.2 Natural products and small molecule agonists Numerous recent literature reports that various natural products and synthetic small molecules can effectively inhibit chondrocyte ferroptosis by activating the SLC7A11/GPX4 axis or the Nrf2GPX4 signaling pathway

In the postnatal murine eye, tip cells at the distal end of endothelial sprouts, which express high levels of endothelial cell-specific molecule 1 (Esm1/endocan), are important for the angiogenic expansion of the developing retinal vasculature

Plant & Cell Physiology 51, 190200