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210 Acetyl-CoA then starts the TCA cycle, where NAD + serves as a coenzyme for three rate-limiting enzymes, -ketoglutarate dehydrogenase (KGDH), isocitrate dehydrogenase 3 (IDH3) and malate dehydrogenase (MDH2), to generate NADH

In conjunction, these studies underscore that the inhibition of aspartate and asparagine metabolism, or their deprivation, might be a compelling therapeutic strategy against some tumors
